Apr 19, 2016
Visceral fat is body fat that is stored within the abdominal cavity and is also stored around a number of important internal organs such as the liver, pancreas and intestines. Unlike subcutaneous fat, or the fat stored directly under the skin, visceral fat is dangerous. Visceral fat is also known as ‘active fat’ because this type of fat can affect the way hormones functions in our body. Higher amounts of visceral fat are associated with increased risks of a number of health problems including diabetes.To Know More
A systematic review of the evidence; Stephen Whiting, Emma Derbyshire, B.K. Tiwari;Appetite 59 (2012) 341–348
Capsaicinoids are a group of chemicals found in chilli peppers, with bioactive properties. The purpose of this study is to systematically review research investigating the potential benefits capsaicinoid compounds may have in relation to weight management. Medical databases were searched and 90 trials found, 20 of which were selected for inclusion, involving 563 participants. Three main areas of potential benefit for weight management were found: (1) increased energy expenditure; (2) increased lipid oxidation and (3) reduced appetite. Trial duration, dosage and sized varied, though trials were generally of high quality with a low risk of bias. It was observed that consumption of capsaicinoids increases energy expenditure by approximately 50 kcal/day, and that this would produce clinically significant levels of weight loss in 1–2 years. It was also observed that regular consumption significantly reduced abdominal adipose tissue levels and reduced appetite and energy intake. The mechanism of action is not presently fully understood, although it is well accepted much of the effects are caused by stimulation of the TRPV1 receptor. While capsaicinoids are not a magic bullet for weight loss, the evidence is that they could play a beneficial role, as part of a weight management program.To Know More
Yu-Hua Tseng, Aaron M. Cypess, and C. Ronald Kahn;Nat Rev Drug Discov. 2010 June; 9(6): 465–482.
Obesity develops when energy intake exceeds energy expenditure. While most current obesity therapies are focused on reducing caloric intake, recent data suggest that increasing cellular energy expenditure (bioenergetics) may be an attractive alternative approach. This is especially true for adaptive thermogenesis - the physiological process whereby energy is dissipated in the form of heat in response to external stimuli. There have been significant recent advances in identifying factors that control the development and function of these tissues and in techniques to measure brown fat in human adults. In this review, we integrate these developments in relation to the classic understandings of cellular bioenergetics to explore the potential for developing novel anti-obesity therapies that target cellular energy expenditure.To Know More